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14.11. Increased weight loading reduces body weight and body fat in obese subjects - A proof of concept randomized clinical trial

C Ohlsson , E Gidestrand , J Bellman , C Larsson , V Palsdottir , D Hagg , PA Jansson , JO Jansson

To read the full abstract: EClinicalMedicine. 2020 Apr 30;22:100338. doi: 10.1016/j.eclinm.2020.100338.The gravitostat hypothesis was only recently proposed based on studies in rodents showing that the addition of external weights to the body limits the rate of weight gain, independent of leptin signalling. In rodents, this was achieved by inserting weighted balloons into the abdomina...

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ey0016.15-18 | (1) | ESPEYB16

15.18. The gravitostat regulates fat mass in obese male mice while leptin regulates fat mass in lean male mice

C Ohlsson , DA Hagg , F Hammarhjelm , A Dalmau Gasull , J Bellman , SH Windahl , V Palsdottir , JO Jansson

To read the full abstract: Endocrinology. 2018 Jul 1;159(7):26762682.The authors compared the effects of leptin versus weight loading using intraperitoneal weighted capsules (gravitostat stimulation) on changes in fat mass in mice. Leptin infusion suppressed body weight and fat mass in lean but not in overweight or obese mice. Weight loading decreased body weight in ove...

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ESPE Yearbook of Paediatric Endocrinology

14.11. Increased weight loading reduces body weight and body fat in obese subjects - A proof of concept randomized clinical trial

15.18. The gravitostat regulates fat mass in obese male mice while leptin regulates fat mass in lean male mice

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